筑波大学大学院　数理物質科学研究科　物性・分子工学専攻　DNAナノシステム研究室

Shingo Nakao and Motoi Oishi*
“Rational Design of a Fluorescence-Amplified Aptasensor Based on Enzyme-Assisted Target Recycling Strategy”
Chemistry Letters (2013) 42, 1122-1124. (IF: 1.62)
(DOI:10.1246/cl.130439)

Hironobu Yasui, Ryo Takeuchi, Tohru Yamamori, Shunsuke Meike, Yoshinari Nakamura, Masaki Nagane, Yasuhiro Kon, Hiroki Murotani, Motoi Oishi, Yukio Nagasaki, and Osamu Inanami
“Radiosensitization of Tumor Cells through Endoplasmic Reticulum Stress Induced by PEGylated Nanogel Containing Gold Nanoparticles”
Cancer Letters (2014) 347, 151-158.

Shogo Sumitani, Motoi Oishi, Tatsuya Yaguchi, Hiroki Murotani, Yukichi Horiguchi, Minoru Suzuki, Koji Ono, Hironobu Yanagie, and Yukio Nagasaki
“Pharmacokinetics of Core-Polymerized, Boron-Conjugated Micelles Designed for Boron Neutron Capture Therapy for Cancer”
Biomaterials (2012) 33, 3568-3577.

Yuya Shinohara, Goshu Tamura, Atsushi Tamura, Yusuke Sanada, Motoi Oishi, Isamu Akiba, Yukio Nagasaki, Kazuo Sakurai, and Yoshiyuki Amemiya
“Dependence of Swelling Behavior of pH-responsive PEG-modified Nanogel on Cross-link Density”
Polymer Journal (2012) 44, 240-244.

Shogo Sumitani, Motoi Oishi, and Yukio Nagasaki
“Carborane Confined Nanoparticles for Boron Neutron Capture Therapy: Improved Stability, Blood Circulation Time and Tumor Accumulation”
Reactive & Functional Polymers (2011) 71, 684-693.

Hiroto Hatakeyama, Hidetaka Akita, Erika Itho, Yasuhiro Hayashi, Motoi Oishi, Yukio Nagasaki, Radostin Danev, Kuniaki Nagayama, Noritada Kaji, Hiroshi Kikuchi, Yoshinobu Baba, and Hideyoshi Harashima
“Systemic Delivery of siRNA to Tumors Using a Lipid Nanoparticle Containing a Tumor Specific Cleavable PEG-lipid”
Biomaterials (2011) 32, 4306-4316.

Atsushi Tamura, Motoi Oishi, and Yukio Nagasaki
“Efficient siRNA Delivery Based on PEGylated and Partially Quaternized Polyamine Nanogels: Enhanced Gene Silencing Activity by the Cooperative Effect of Tertiary and Quaternary Amino Groups in the Core”
Journal of Controlled Release (2010) 146, 378-387.

Motoi Oishi, and Yukio Nagasaki
“Stimuli-Responsive Smart Nanogels for Cancer Diagnostics and Therapy”
Nanomedicine (2010) 5, 451-468.

Takahito Nakamura, Atsushi Tamura, Hiroki Murotani, Motoi Oishi, Yuta Jinji, Kiyoto Matsuishi, and Yukio Nagasaki
“Large Payloads of Gold Nanoparticles into the Polyamine Network Core of Stimuli-Responsive PEGylated Nanogels for Selective and Noninvasive Cancer Photothermal Therapy”
Nanoscale (2010) 2, 739-746.

Hitoshi　Furusho, Motoi Oishi, Tetsuo Kishi, Atsuo Yasumori, and Yukio Nagasaki
“Preparation and Molecular Recognition of SERS Probe Based on Gold Nanoparticles Constructed from PEG-Oligoamine Copolymer Possessing a Coumarin Group between PEG and Oligoamine”
Chemistry Letters (2010) 39, 52-53.

Motoi Oishi, Takahito Nakamura, Yuta Jinji, Kiyoto Matsuishi, and Yukio Nagasaki
“Multi-Stimuli-Triggered Release of Charged Dye from Smart PEGylated Nanogels Containing Gold Nanoparticles to Regulate Fluorescence Signals”
Journal of Materials Chemistry (2009) 19, 5909-5912.

Hiroto Hatakeyama, Erika Itho, Hidetaka Akita, Motoi Oishi, Yukio Nagasaki, Shiroh Futaki, and Hideyoshi Harashima
“A pH-Sensitive Fusogenic Peptide Facilitates Endosomal Escape and Greatly Enhances the Gene Silencing of siRNA-Containing Nanoparticles in vitro and in vivo”
Journal of Controlled Release (2009) 139, 127-132.

Atsushi Tamura, Motoi Oishi, and Yukio Nagasaki
“Enhanced Cytoplasmic Delivery of siRNA Using the Stabilized Polyion Complexes Based on PEGylated Nanogels Bearing Cross-Linked Polyamine Structure”
Biomacromolecules (2009) 10, 1818-1827.

Yu Sakurai, Hiroto Hatakeyama, Hidetaka Akita, Motoi Oishi, Yukio Nagasaki Shiro Futaki, Hideyoshi Harashima
“Efficient Short Interference RNA Delivery to Tumor Cells Using a Combination of Octaarginine, GALA and Tumor-Specific, Cleavable Polyethylene Glycol System”
Biological & Pharmaceutical Bulletin (2009) 32, 928-932.

Yusuke Kawakami, Yuriko Kakihana, Osamu Ooi, Motoi Oishi, Keigo Suzuki, Satoshi Shinke and Kazuya Uenishi
“Control of Stereochemical Structure of Silicon-Containing Polymeric Systems”
Polymer International (2009) 58, 279-284.

Motoi Oishi, Atsushi Tamura, Takahito Nakamura, and Yukio Nagasaki
“A Smart Nanoprobe Based on Fluorescence-Quenching PEGylated Nanogel Containing Gold Nanoparticles for Monitoring the Cancer Response to Therapy”
Advanced Functional Materials (2009) 19, 827-834.

Motoi Oishi, Shogo Sumitani, Tatiana K. Bronich, Alexander V. Kabanov, Michael D. Boska, and Yukio Nagasaki
“Novel Tumor-specific 19F-MRS/I Nanoprobe based on pH-Responsive PEGylated Nanogel: pH-Dependent 19F-Magnetic Resonance Studies”
Chemistry Letters (2009) 38, 128-129.

Xiaofei Yuan, Michihiro Iijima, Motoi Oishi, and Yukio Nagasaki
“Structure and Activity Assay of Nanozymes Prepared by the Co-immobilization of Practically Useful Enzymes and Hydrophilic Block Copolymers on Gold Nanoparticles”
Langmuir (2008) 24, 6903-6909.

Daisuke Miyamoto, Motoi Oishi, Keiji Kojima, Keitaro Yoshimoto, and Yukio Nagasaki
“Completely Dispersible PEGylated Gold Nanoparticles under Physiological Conditions: Modification of Gold Nanoparticles with Precisely Controlled PEG-b-Polyamine”
Langmuir (2008) 24, 5010-5017.

Motoi Oishi, Shogo Sumitani, and Yukio Nagasaki
“On-Off Regulation of 19F Magnetic Resonance Signals Based on pH-Sensitive PEGylated Nanogels for Potential Tumor-Specific Smart 19F MRI Probes"
Bioconjugate Chemistry (2007) 18, 1379-1382.

Motoi Oishi, Hisato Hayashi, Michihiro Iijima, and Yukio Nagasaki
“Endosomal Release and Intracellular Delivery of Anticancer Drugs Using pH-Sensitive PEGylated Nanogels"
Journal of Materials Chemistry (2007) 17, 3720-3725.

Motoi Oishi, Yukio Nagasaki, Nobuhiro Nishiyama, Keiji Itaka, Motoki Takagi, Akira Shimamoto, Yasuhiro Furuichi, and Kazunori Kataoka
“Enhanced Growth Inhibition of Hepatic Multicellular Tumor Spheroids by Lactosylated Poly(ethylene glycol)-siRNA Conjugate Formulated in PEGylated Polyplexes"
ChemMedChem (2007) 2, 1290-1297.

Motoi Oishi, Naoki Miyagawa, Takeshi Sakura and Yukio Nagasaki
“pH-Responsive PEGylated Nanogel Containing Platinum Nanoparticles: Application to On-Off Regulation of Catalytic Activity for Reactive Oxygen Species"
Reactive & Functional Polymers (2007) 67, 662-668.

Motoi Oishi, Hisato Hayashi, Teppei Uno, Takehiko Ishii, Michihiro Iijima, and Yukio Nagasaki
“One-Pot Synthesis of pH-Responsive PEGylated Nanogels Containing Gold Nanoparticles by Autoreduction of Chloroaurate Ions within Nanoreactors”
Macromolecular Chemistry & Physics (2007) 208, 1176-1182.

Motoi Oishi, Hisato Hayashi, Keiji Itaka, Kazunori Kataoka, and Yukio Nagasaki
“pH-Responsive PEGylated Nanogels as Targetable and Low Invasive Endosomolytic Agents to Induce the Enhanced Transfection Efficiency of Nonviral Gene Vectors”
Colloid & Polymer Science (2007) 285, 1055-1060.

Motoi Oishi, Satsohi Ikeo, and Yukio Nagasaki
“Lipase-Catalyzed Selective Synthesis and Micellization of Poly(ethylene glycol)-block-Poly(-caprolactone) Copolymer Possessing a Carboxylic Acid Group at the PEG Chain End”
Polymer Journal (2007) 39, 239-244.

Hiroto Hatakeyama, Hidetaka Akita, Motoi Oishi, Yukio Nagasaki, Hideo Kobayashi, Hiroshi Kikuchi and Hideyoshi Harashima
“Development of a Novel Systemic Gene Delivery System for Cancer Therapy with a Tumor-Specific Cleavable PEG-lipid”
Gene Therapy (2007) 14, 68-77.

Motoi Oishi, and Yukio Nagasaki
“Synthesis, Characterization, and Biomedical Applications of Core-Shell-Type Stimuli-Responsive Nanogels -Nanogel Composed of Poly[2-(N,N-diethylamino)ethyl methacrylate] Core and PEG Tethered Chains-”
Reactive & Functional Polymers (2007) 67, 1311-1329.

Motoi Oishi, Junpei Nakaogami, Takehiko Ishii, and Yukio Nagasaki
“Smart PEGylated Gold Nanoparticles for the Cytoplasmic Delivery of siRNA to Induce Enhanced Gene Silencing”
Chemistry Letters (2006) 35, 1046-1047.

Motoi Oishi, Kazunori Kataoka, and Yukio Nagasaki
“pH-Responsive Three-Layered PEGylated Polyplex Micelle Based on Lactosylated ABC Triblock Copolymer as Targetable and Endosomal-Disruptive Nonviral Gene Vector”
Bioconjugate Chemistry (2006) 17, 677-688.

Md. Monsur Ali, Motoi Oishi, Fumi Nagastugi, Kenya Mori, Yukio Nagasaki, Kazunori Kataoka, and Shigeki Sasaki
“Intracellular Ability of an Inducible Alkylation System to Exhibit Antisense Effects with Greater Potency and Selectivity”
Angewandte Chemie International Edition (2006) 45, 3136-3140.

Motoi Oishi, Tetsuya Hayama, Yoshitsugu Akiyama, Seiji Takae, Atsushi Harada, Yuichi Yamasaki, Fumi Nagastugi, Shigeki Sasaki, Yukio Nagasaki, and Kazunori Kataoka
“Supramolecular Assemblies for the Cytoplasmic Delivery of Antisense Oligodeoxynucleotide: Polyion Complex (PIC) Micelles Based on Poly(ethylene glycol)-SS-Oligodeoxynucleotide Conjugate”
Biomacromolecules (2005) 6, 2449-2454.

Motoi Oishi, Yukio Nagasaki, Keiji Itaka, Nobuhiro Nishiyama, and Kazunori Kataoka
“Lactosylated Poly(ethylene glycol)-siRNA Conjugate through Acid-Labile β-Thiopropionate Linkage to Construct pH-sensitive Polyion Complex Micelles Achieving Enhanced Gene Silencing in Hepatoma Cells”
Journal of the American Chemical Society (2005) 127, 1624-1625.

Motoi Oishi, Fumi Nagatsugi, Shigeki Sasaki, Yukio Nagasaki, and Kazunori Kataoka
“Smart Polyion Complex Micelles for Targeted Intracellular Delivery of PEGylated Antisense Oligonucleotide with Acid-Labile linkage”
ChemBioChem (2005) 6, 718-725.

Yusuke Kawakami, Yuning Li, Yang Liu, Makoto Seino, Chitsakon Pakjamsai, Motoi Oishi, Young Hee Cho, and Ichiro Imae
“Control of Molecular Weight, Stereochemistry and Higher Order Structure of Siloxane-containing Polymers and Their Functional Design”
Macromolecular Research (2004) 12, 156-171.

Yusuke Kawakami, Ichiro Imae, Motoi Oishi, Makoto Seino, and Yang Liu
"High Performance Siloxane-Containing Polymers”"
Molecular Crystals & Liquid Crystals (2004) 415, 75-92.

Motoi Oishi, Shigeki Sasaki, Yukio Nagasaki, and Kazunori Kataoka
“pH-Responsive Oligodeoxynucleotide (ODN)-Poly(ethylene glycol) Conjugate through Acid-Labile β-Thiopropionate Linkage: Preparation and Polyion Complex Micelle Formation”
Biomacromolecules (2003) 4, 1426-1432.

Yusuke Kawakami, Sung Young Park, Kazuya Uenishi, Motoi Oishi, and Ichiro Imae
“Controlled Synthesis of Silicon–Containing Polymers by Metal Catalysts”
Polymer International (2003) 52, 1619-1624.

Motoi Oishi, Maki Minakawa, Ichiro Imae, and Yusuke Kawakami
“Synthesis and Characterization of Optically Active Hyperbranched Poly(carbosiloxane)s”
Macromolecules (2002) 35, 4938-4945.

Makoto Seino, Motoi Oishi, Ichiro Imae, and Yusuke Kawakami
“Formation of Poly(silsesquioxane) Gel Containing Optically Active 1,3-Dimethyl-1,3-diphenyldisiloxane as a Connecting Unit”
Polymer Journal (2002) 34, 43-47.

Motoi Oishi and Yusuke Kawakami
“A Novel Catalyst System for Cationic Polymerization of Styrene Derivatives. Combination of Platinum (0) Complex and Methyldichlorosilane”
Polymer Journal (2001) 33, 765-772.

Motoi Oishi, Jeong-Yeol Moon, Wanida Janvikul, and Yusuke Kawakami
“Synthesis of Poly(methylphenylsiloxane) Rich in Syndiotacticity by Rh-Catalysed Stereoselective Cross-Dehydrocoupling Polymerization of Optically Active 1,3-Dimethyl-1,3-diphenyldisiloxane Derivatives”
Polymer International (2001) 50, 135-143.

Motoi Oishi and Yusuke Kawakami
“Synthesis of Stereoregular and Optically Active Polysiloxanes Containing 1,3-Dimethyl-1,3-diphenyldisiloxane as a Constitutional Unit”
Macromolecules (2000) 33, 1960-1963.

Motoi Oishi, Jeong-Yeol Moon, Eiji Shirakawa, and Yusuke Kawakami
“Stereo-Recognition of Propagating Chain End in the Cross-Dehydrocoupling Polymerization of meso-1,3-Dimethyl-1,3-diphenyldisiloxanediol with Methylphenylsilane”
Polymer Journal (2000) 32, 980-983.

Tsutomu Yokozawa, Motoi Oishi, and Yasukazu Tanaka
“Spontaneous Addition of Active Methine Compounds to Enol Ethers and α,β-Unsaturated Ketones in Aprotic Polar Solvent”
The Journal of Organic Chemistry (2000) 65, 1895-1897.

Motoi Oishi and Yusuke Kawakami
“A Stereoselective Approach to Optically Active Bifunctional 1,3-Dimethyl-1,3-diphenyldisiloxanes”
Organic Letters (1999) 1, 549-551.